At Matriskin, every formula is backed by science and verified through independent clinical testing.

Our biotechnology-driven actives are measured for visible, quantifiable improvements in skin health — from hydration and firmness to wrinkle reduction and barrier repair. On this page, you’ll find the key results from our clinical studies, along with the products responsible for each outcome.

Clinical Claim

Deep wrinkles reduced by 68% in 6 months

Evidence Source

Clinical study on 3% Palmitoyl Pentapeptide-4 cream

Associated products:
Clinical Claim:

Collagen synthesis increased by +117% (Collagen I), +327% (Collagen IV), GAGs +267%

Evidence Source

In vitro / ex vivo studies with palmitoyl pentapeptide-4

Associated products:
Clinical Claim

95% of users showed visible reduction in under-eye puffiness

Evidence Source

Clinical morphometric study of peptide blend

Associated products:
Clinical Claim:

Skin elasticity improved by 35% in 30 days

Evidence Source

Clinical documentation in training references

Associated products:
Clinical Claim

Instant wrinkle smoothing within 5 minutes (Sesame Protein Complex)

Evidence Source

Documented in key ingredients file

Associated products:
Clinical Claim:

Hydration boosted in 90% of users (Hyaluronic Acid + Collagen)

Evidence Source

Clinical studies on sodium hyaluronate and hydrolyzed collagen

Associated products:
Clinical Claim

Improved skin redness and dryness by 66–100%

Evidence Source

Clinical study on high MW sodium hyaluronate

Associated products:
Clinical Claim:

Hydrolyzed collagen improves symptoms in 79.8% of users

Evidence Source

Hydrolyzed marine collagen studies

Associated products:
Clinical Claim

80% of volunteers saw visible wrinkle reduction; better tolerated than Vitamin C

Evidence Source

6-month comparative clinical study

Associated products:
Clinical Claim:

Protects against pollution / oxidative stress (biosaccharide gum-4 second-skin effect)

Evidence Source

In vivo and in vitro tests

Associated products:
Clinical Claim

Speeds recovery, reduces irritation post-procedure

Evidence Source

Scientific validation for accelerated healing

Associated products:

ESPA DATA SOURCES AND REFERENCES

MATRISKIN 

American Academy of Dermatology Association. DermPractice Info. Guidelines of Care for Photoaging/Photodamage. www.aadassociation.org. Aad (American academy of dermatologist) aad.org  Fitzpatrick's Dermatology in General Medicine, WebMd; CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.;  NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov. aad D.L. Bissett, J.E. Oblong, C.A. Berge: niacinamide (a B vitamin that improves aging facial skin appearance) (Dermatol Surg, 2005-7; 31 (7.2): 860-5); Biologie moléculaire de la cellule (3ème, IV; Médecine Sciences/Flammarion); Canola Council (http://www.canolacouncil.org); C.R. Cardoso, S. Favoreto Jr, L.L. Oliveira, J.O. Vancim, G.B. Barban, D.B. Ferraz, J.S. Silva: oleic acid modulation of the immune response in wound healing: a new approach for skin repair (Immunobiology, 2011-03; 216 (3): 409-15); Cosmétologie: vieillissement (faux miracles et vrais progrès), 1996-01, p. 6; V.R. Chandrasekaran, D.Z. Hsu, M.Y. Liu: beneficial effect of sesame oil on heavy metal toxicity (JPEN, 2014-02; 38 (2): 17985); Thivolet & Schmitt: vieillissement cutané (7ème cours de biologie de la peau; séminaire INSERM 1993, p. 251); Gallot, "les protéoglycanes", actifs & additifs en cosmétologie (Lavoisier TEC & DOC, p. 110-124, 1992); T. Geetha, B. Rohit, K.I. Pal: sesamol (an efficient antioxidant with potential therapeutic benefits) (Med Chem, 2009-07; 5 (4): 367-71); W. Gehring: nicotinic acid/niacinamide and the skin (J Cosm Dermatol, 2004; 3 (2): 88-93); M. Ginsberg, M.D. Pierschbacher, E. Ruoslahti, G. Marguerie, E. Plow: inhibition of fibronectin binding to platelets by proteolytic fragments and synthetic peptides which support fibroblast adhesion (J Biol Chem, 1985- 04-10; 260 (7): 3931-6); Huey-Jine Chai, JingHua Li, Han-Ning Huang, Tsung-Lin Li, Yi-Lin Chan, Chyuan-Yuan Shiau & Chang-Jer Wu: effects of sizes and conformations of fish-scale collagen peptides on facial skin qualities and transdermal penetration efficiency (J Biomed Biotechnol, 2010; 757301); K. Katayama, J.M. Seyer, R. Raghow, A.H. Kang: regulation of extracellular matrix production by chemically synthesized subfragments of type I collagen carboxy propeptide (Biochemistry, 1991-07-23; 30 (29): 7097-104); K. Katayama, J. Armendariz-Borunda, R. Raghow, A.H. Kang, J.M. Seyer: a pentapeptide from type I procollagen promotes extracellular matrice production (J Biol Chem, 1993; 268 (14), p. 9941); Y. Kaymac & M. Önder: an investigation of efficacy of topical niacinamide for the treatment of mild and moderate acne vulgaris (J Turk Acad Dermatol, 2008; 2 (4): 4); R.R. Korać, K.M. Khambholja: potential of herbs in skin protection from ultraviolet radiation (Pharmacogn Rev, 2011-07; 5 (10): 164-73); K. Lintner, O. Peschard: biologically active peptides (from a laboratory bench curiosity to a functional skin care product) (Int J Cosmet Sci, 2000-06; 22 (3): 207-18); Thivolet & Schmitt: lipides cutanés (7th skin biology course; INSERM, 1993, p. 43-53); H. Matsumoto, H. Ohara, K. Ito, Y. Nakamura & S. Takahashi: clinical effects of fish type I collagen hydrolysate on skin properties (ITE Letters on Batteries, New Technologies & Medicine, 2006; 7 (4): 386-390); Monte Alto Costa et al.: fibroblaste et réparation cutanée (8ème cours de biologie de la peau; séminaire INSERM, 1995, p. 203; Thivolet & Schmitt); N.M. Niren: pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions (Cutis, 2006-01; 77 (1 suppl.): 11-6); Owen et al.: anti-ageing technology for skincare (Global Cosmetic Industry, 1999/02, p. 38-40); N. Pazyar, R. Yaghoobi, M.R. Ghassemi, A. Kazerouni, E. Rafeie, N. Jamshydian: jojoba in dermatology (a succinct review) (G Ital Dermatol Venereol, 2013; 148 (6): 687-91); L.M. Pereira, E. Hatanaka, E.F. Martins, F. Oliveira, E.A. Liberti, S.H. Farsky, R. Curi, T.C. Pithon-Curi: effect of oleic and linoleic acids on the inflammatory phase of wound healing in rats (Cell Biochem Funct, 2008-03/04; 26 (2): 197-204); Pierard et al.: the microanatomical basis of facial frown lines (Arch Dermatol, 1989; 125 (8), p. 1090); Ponec, Gibbs, Weerheim, Kempenaar, Mulder & Mommaas: epidermal growth factor and temperature regulate keratinocytes differentiation (Arch Dermatol Res, 1997, p. 289, 317- 326); E. Ranzatto, S. Martinotti & B. Burlando: wound healing properties of jojoba liquid wax: an in vitro study (J Ethnopharmacol,2011; 134 (2): 443-9); L. Robert: gerontology (press office of the Novartis Company, 1997); Roelandts: ageing and photoaging in 'Cosmetic Dermatology' (1994, 7.8, Martin Dunitz Editions); R.R. Shenoy, A.T. Sudheendra, P.G. Nayak, P. Paul, N.G. Kutty, C.M. Rao: normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats (J Ethnopharmacol, 2011-01-27; 133 (2): 608-12); M. Srisayam, N. Weerapreeyakul, S. Barusrux, K. Kanokmedhakul: antioxidant, antimelanogenic, and skin-protective effect of sesamol (J Cosmet Sci, 2014-03/04; 65 (2): 69-79); D. Surjana, D.L. Damian: nicotinamide in dermatology and photoprotection (Skinmed, 2011-11/12; 9 (6): 360-5); T. Tsuji, T. Yorifuji, Y. Hayashi, T. Hamada: light and electron microscopy studies on wrinkles in aged skin (Br J Dermatol, 1986; 114, 

(3), p. 329); T. Tsuji: ultrastructure of deep wrinkles in the elderly (J Cutan Pathol, 1987; 14 (3), p. 158); J.W. Wiechers, A.V. Rawlings, C. Garcia, C. Chesné, P. Balaguer, J.C. Nicolas, S. Corre, M.D. Galibert: a new mechanism of action for skin whitening agents (binding to the peroxisome proliferator-activated receptor) (Int J Cosmet Sci, 2005-04; 27 (2): 123-32).